diff --git a/rest_api/controller/file_upload.py b/rest_api/controller/file_upload.py
index d3d34a209..5dff2dbb0 100644
--- a/rest_api/controller/file_upload.py
+++ b/rest_api/controller/file_upload.py
@@ -21,14 +21,15 @@ try:
         path=Path(PIPELINE_YAML_PATH), pipeline_name=INDEXING_PIPELINE_NAME, overwrite_with_env_variables=True
     )
     # Since each instance of FAISSDocumentStore creates an in-memory FAISS index, the Indexing & Query Pipelines would
-    # end up with different indices. The check below prevents creation of Indexing Pipelines with FAISSDocumentStore.   
-    is_faiss_present = False
+    # end up with different indices. The same applies for InMemoryDocumentStore. The check below prevents creation of 
+    # Indexing Pipelines with FAISSDocumentStore or InMemoryDocumentStore.   
+    is_faiss_or_inmemory_present = False
     for node in pipeline_config["nodes"]:
-        if definitions[node["name"]]["type"] == "FAISSDocumentStore":
-            is_faiss_present = True
+        if definitions[node["name"]]["type"] == "FAISSDocumentStore" or definitions[node["name"]]["type"] == "InMemoryDocumentStore":
+            is_faiss_or_inmemory_present = True
             break
-    if is_faiss_present:
-        logger.warning("Indexing Pipeline with FAISSDocumentStore is not supported with the REST APIs.")
+    if is_faiss_or_inmemory_present:
+        logger.warning("Indexing Pipeline with FAISSDocumentStore or InMemoryDocumentStore is not supported with the REST APIs.")
         INDEXING_PIPELINE = None
     else:
         INDEXING_PIPELINE = Pipeline.load_from_yaml(Path(PIPELINE_YAML_PATH), pipeline_name=INDEXING_PIPELINE_NAME)