diff --git a/packages/core/admin/admin/src/content-manager/components/RelationInput/RelationInput.js b/packages/core/admin/admin/src/content-manager/components/RelationInput/RelationInput.js
index 653cda5278..a8fdb2cad9 100644
--- a/packages/core/admin/admin/src/content-manager/components/RelationInput/RelationInput.js
+++ b/packages/core/admin/admin/src/content-manager/components/RelationInput/RelationInput.js
@@ -2,6 +2,7 @@ import React, { useRef, useState, useMemo, useEffect } from 'react';
 import PropTypes from 'prop-types';
 import styled from 'styled-components';
 import { FixedSizeList as List } from 'react-window';
+import { useIntl } from 'react-intl';
 
 import { ReactSelect } from '@strapi/helper-plugin';
 import { Status } from '@strapi/design-system/Status';
@@ -12,6 +13,7 @@ import { FieldLabel, FieldError, FieldHint, Field } from '@strapi/design-system/
 import { TextButton } from '@strapi/design-system/TextButton';
 import { Typography } from '@strapi/design-system/Typography';
 import { Tooltip } from '@strapi/design-system/Tooltip';
+import { VisuallyHidden } from '@strapi/design-system/VisuallyHidden';
 
 import Cross from '@strapi/icons/Cross';
 import Refresh from '@strapi/icons/Refresh';
@@ -22,6 +24,8 @@ import { RelationList } from './components/RelationList';
 import { Option } from './components/Option';
 import { RELATION_GUTTER, RELATION_ITEM_HEIGHT } from './constants';
 
+import { getTrad } from '../../utils';
+
 const LinkEllipsis = styled(Link)`
   white-space: nowrap;
   overflow: hidden;
@@ -76,9 +80,13 @@ const RelationInput = ({
   size,
 }) => {
   const [value, setValue] = useState(null);
+  const [overflow, setOverflow] = useState('');
+  const [liveText, setLiveText] = useState('');
+
   const listRef = useRef();
   const outerListRef = useRef();
-  const [overflow, setOverflow] = useState('');
+
+  const { formatMessage } = useIntl();
 
   const { data } = searchResults;
 
@@ -213,12 +221,68 @@ const RelationInput = ({
     onSearch();
   };
 
+  /**
+   *
+   * @param {number} newIndex
+   * @param {number} currentIndex
+   *
+   * @returns {void}
+   */
   const handleUpdatePositionOfRelation = (newIndex, currentIndex) => {
-    if (onRelationReorder) {
+    if (onRelationReorder && newIndex >= 0 && newIndex < relations.length) {
       onRelationReorder(currentIndex, newIndex);
+
+      const item = relations[currentIndex];
+      setLiveText(`${item.mainField ?? item.id}. New position in list: ${getItemPos(newIndex)}`);
     }
   };
 
+  /**
+   *
+   * @param {number} index
+   * @returns {string}
+   */
+  const getItemPos = (index) => `${index + 1} of ${relations.length}`;
+
+  /**
+   *
+   * @param {number} index
+   * @returns {void}
+   */
+  const handleGrabItem = (index) => {
+    const item = relations[index];
+
+    setLiveText(
+      `${item.mainField ?? item.id}, grabbed. Current position in list: ${getItemPos(
+        index
+      )}. Press up and down arrow to change position, Spacebar to drop, Escape to cancel.`
+    );
+  };
+
+  /**
+   *
+   * @param {number} index
+   * @returns {void}
+   */
+  const handleDropItem = (index) => {
+    const item = relations[index];
+
+    setLiveText(
+      `${item.mainField ?? item.id}, dropped. Final position in list: ${getItemPos(index)}`
+    );
+  };
+
+  /**
+   *
+   * @param {number} index
+   * @returns {void}
+   */
+  const handleCancel = (index) => {
+    const item = relations[index];
+
+    setLiveText(`${item.mainField ?? item.id}, dropped. Re-order cancelled.`);
+  };
+
   return (
     <Field error={error} name={name} hint={description} id={id}>
       <Relation
@@ -287,6 +351,13 @@ const RelationInput = ({
         }
       >
         <RelationList overflow={overflow}>
+          <VisuallyHidden id={`${name}-item-instructions`}>
+            {formatMessage({
+              id: getTrad('components.RelationInput.instructions'),
+              defaultMessage: `Press spacebar to grab and re-order`,
+            })}
+          </VisuallyHidden>
+          <VisuallyHidden aria-live="assertive">{liveText}</VisuallyHidden>
           <List
             height={dynamicListHeight}
             ref={listRef}
@@ -294,7 +365,11 @@ const RelationInput = ({
             itemCount={totalNumberOfRelations}
             itemSize={RELATION_ITEM_HEIGHT + RELATION_GUTTER}
             itemData={{
+              ariaDescribedBy: `${name}-item-instructions`,
               disabled,
+              handleCancel,
+              handleDropItem,
+              handleGrabItem,
               labelDisconnectRelation,
               onRelationDisconnect,
               publicationStateTranslations,
@@ -395,7 +470,11 @@ RelationInput.propTypes = {
  */
 const ListItem = ({ data, index, style }) => {
   const {
+    ariaDescribedBy,
     disabled,
+    handleCancel,
+    handleDropItem,
+    handleGrabItem,
     labelDisconnectRelation,
     onRelationDisconnect,
     publicationStateTranslations,
@@ -409,11 +488,11 @@ const ListItem = ({ data, index, style }) => {
 
   return (
     <RelationItem
-      disabled={disabled}
+      ariaDescribedBy={ariaDescribedBy}
       canDrag={canDrag}
+      disabled={disabled}
       id={id}
       index={index}
-      updatePositionOfRelation={updatePositionOfRelation}
       endAction={
         <DisconnectButton
           data-testid={`remove-relation-${id}`}
@@ -425,11 +504,15 @@ const ListItem = ({ data, index, style }) => {
           <Icon width="12px" as={Cross} />
         </DisconnectButton>
       }
+      onCancel={handleCancel}
+      onDrop={handleDropItem}
+      onGrab={handleGrabItem}
       style={{
         ...style,
         bottom: style.bottom ?? 0 + RELATION_GUTTER,
         height: style.height ?? 0 - RELATION_GUTTER,
       }}
+      updatePositionOfRelation={updatePositionOfRelation}
     >
       <BoxEllipsis minWidth={0} paddingTop={1} paddingBottom={1} paddingRight={4}>
         <Tooltip description={mainField ?? `${id}`}>
@@ -462,7 +545,11 @@ ListItem.defaultProps = {
 
 ListItem.propTypes = {
   data: PropTypes.shape({
+    ariaDescribedBy: PropTypes.string.isRequired,
     disabled: PropTypes.bool.isRequired,
+    handleCancel: PropTypes.func,
+    handleDropItem: PropTypes.func,
+    handleGrabItem: PropTypes.func,
     labelDisconnectRelation: PropTypes.string.isRequired,
     onRelationDisconnect: PropTypes.func.isRequired,
     publicationStateTranslations: PropTypes.shape({
diff --git a/packages/core/admin/admin/src/content-manager/components/RelationInput/components/RelationItem.js b/packages/core/admin/admin/src/content-manager/components/RelationInput/components/RelationItem.js
index 524cf617c3..f3481ce526 100644
--- a/packages/core/admin/admin/src/content-manager/components/RelationInput/components/RelationItem.js
+++ b/packages/core/admin/admin/src/content-manager/components/RelationInput/components/RelationItem.js
@@ -1,4 +1,4 @@
-import React, { useRef } from 'react';
+import React, { useRef, useState } from 'react';
 import PropTypes from 'prop-types';
 import styled from 'styled-components';
 import { useDrag, useDrop } from 'react-dnd';
@@ -10,6 +10,7 @@ import { IconButton } from '@strapi/design-system/IconButton';
 import Drag from '@strapi/icons/Drag';
 
 import { composeRefs } from '../../../utils';
+import { RELATION_GUTTER } from '../constants';
 
 const ChildrenWrapper = styled(Flex)`
   width: 100%;
@@ -20,6 +21,7 @@ const ChildrenWrapper = styled(Flex)`
 const RELATION_ITEM_DRAG_TYPE = 'RelationItem';
 
 export const RelationItem = ({
+  ariaDescribedBy,
   children,
   canDrag,
   disabled,
@@ -27,9 +29,13 @@ export const RelationItem = ({
   style,
   id,
   index,
+  onCancel,
+  onDropItem,
+  onGrabItem,
   updatePositionOfRelation,
   ...props
 }) => {
+  const [isSelected, setIsSelected] = useState(false);
   const relationRef = useRef(null);
 
   const [{ handlerId }, dropRef] = useDrop({
@@ -85,8 +91,84 @@ export const RelationItem = ({
 
   const composedRefs = composeRefs(relationRef, dragRef);
 
+  /**
+   * @type {(movement: 'UP' | 'DOWN') => void})}
+   */
+  const handleMove = (movement) => {
+    if (!isSelected) {
+      return;
+    }
+
+    if (movement === 'UP') {
+      updatePositionOfRelation(index - 1, index);
+    } else if (movement === 'DOWN') {
+      updatePositionOfRelation(index + 1, index);
+    }
+  };
+
+  const handleDragClick = () => {
+    if (isSelected) {
+      if (onDropItem) {
+        onDropItem(index);
+      }
+      setIsSelected(false);
+    } else {
+      if (onGrabItem) {
+        onGrabItem(index);
+      }
+      setIsSelected(true);
+    }
+  };
+
+  const handleCancel = () => {
+    setIsSelected(false);
+
+    if (onCancel) {
+      onCancel(index);
+    }
+  };
+
+  /**
+   * @type {React.KeyboardEventHandler<HTMLButtonElement>}
+   */
+  const handleKeyDown = (e) => {
+    if (e.key === 'Tab' && !isSelected) {
+      return;
+    }
+
+    e.preventDefault();
+
+    switch (e.key) {
+      case ' ':
+        handleDragClick();
+        break;
+
+      case 'Escape':
+        handleCancel();
+        break;
+
+      case 'ArrowDown':
+      case 'ArrowRight':
+        handleMove('DOWN');
+        break;
+
+      case 'ArrowUp':
+      case 'ArrowLeft':
+        handleMove('UP');
+        break;
+
+      default:
+    }
+  };
+
   return (
-    <Box style={style} as="li" ref={dropRef}>
+    <Box
+      style={style}
+      as="li"
+      ref={dropRef}
+      aria-describedby={ariaDescribedBy}
+      cursor={canDrag ? 'all-scroll' : 'default'}
+    >
       {isDragging ? (
         <Box
           ref={dragPreviewRef}
@@ -99,7 +181,7 @@ export const RelationItem = ({
           borderColor="primary600"
           borderWidth="1px"
           background="primary100"
-          height="100%"
+          height={`calc(100% - ${RELATION_GUTTER}px)`}
         />
       ) : (
         <Flex
@@ -118,7 +200,14 @@ export const RelationItem = ({
         >
           {/* TODO: swap this out for using children when DS is updated */}
           {canDrag ? (
-            <IconButton marginRight={1} aria-label="Drag" noBorder icon={<Drag />} />
+            <IconButton
+              marginRight={1}
+              aria-label="Drag"
+              noBorder
+              icon={<Drag />}
+              onClick={handleDragClick}
+              onKeyDown={handleKeyDown}
+            />
           ) : null}
           <ChildrenWrapper justifyContent="space-between">{children}</ChildrenWrapper>
           {endAction && <Box paddingLeft={4}>{endAction}</Box>}
@@ -129,20 +218,28 @@ export const RelationItem = ({
 };
 
 RelationItem.defaultProps = {
+  ariaDescribedBy: '',
   canDrag: false,
   disabled: false,
   endAction: undefined,
+  onCancel: undefined,
+  onDropItem: undefined,
+  onGrabItem: undefined,
   style: undefined,
   updatePositionOfRelation: undefined,
 };
 
 RelationItem.propTypes = {
+  ariaDescribedBy: PropTypes.string,
   canDrag: PropTypes.bool,
   children: PropTypes.node.isRequired,
   disabled: PropTypes.bool,
   endAction: PropTypes.node,
   id: PropTypes.number.isRequired,
   index: PropTypes.number.isRequired,
+  onCancel: PropTypes.func,
+  onDropItem: PropTypes.func,
+  onGrabItem: PropTypes.func,
   style: PropTypes.shape({
     height: PropTypes.number,
     left: PropTypes.number,
diff --git a/packages/core/admin/admin/src/content-manager/components/RelationInput/components/tests/RelationItem.test.js b/packages/core/admin/admin/src/content-manager/components/RelationInput/components/tests/RelationItem.test.js
index a14030aeb9..1396d4bfaf 100644
--- a/packages/core/admin/admin/src/content-manager/components/RelationInput/components/tests/RelationItem.test.js
+++ b/packages/core/admin/admin/src/content-manager/components/RelationInput/components/tests/RelationItem.test.js
@@ -1,18 +1,23 @@
 import React from 'react';
-import { render } from '@testing-library/react';
+import { render, screen, fireEvent } from '@testing-library/react';
 import { ThemeProvider, lightTheme } from '@strapi/design-system';
 import { DndProvider } from 'react-dnd';
 import { HTML5Backend } from 'react-dnd-html5-backend';
 
 import { RelationItem } from '../RelationItem';
 
-const setup = ({ endAction }) =>
+const setup = ({ endAction, testingDnd = false, ...props }) =>
   render(
     <ThemeProvider theme={lightTheme}>
       <DndProvider backend={HTML5Backend}>
-        <RelationItem id={0} index={0} endAction={endAction}>
+        <RelationItem canDrag={testingDnd} id={0} index={0} endAction={endAction} {...props}>
           First relation
         </RelationItem>
+        {testingDnd ? (
+          <RelationItem canDrag={testingDnd} id={1} index={1} endAction={endAction} {...props}>
+            Second relation
+          </RelationItem>
+        ) : null}
       </DndProvider>
     </ThemeProvider>
   );
@@ -29,4 +34,58 @@ describe('Content-Manager || RelationInput || RelationItem', () => {
 
     expect(getByText('end action here')).toBeInTheDocument();
   });
+
+  describe('Reordering relations', () => {
+    it('should not move with arrow keys if the button is not pressed first', () => {
+      const updatePositionOfRelationMock = jest.fn();
+
+      setup({ updatePositionOfRelation: updatePositionOfRelationMock, testingDnd: true });
+
+      const [draggedItem] = screen.getAllByLabelText('Drag');
+
+      fireEvent.keyDown(draggedItem, { key: 'ArrowDown', code: 'ArrowDown' });
+
+      expect(updatePositionOfRelationMock).not.toBeCalled();
+    });
+
+    it('should move with the arrow keys if the button has been activated first', () => {
+      const updatePositionOfRelationMock = jest.fn();
+
+      setup({ updatePositionOfRelation: updatePositionOfRelationMock, testingDnd: true });
+
+      const [draggedItem] = screen.getAllByLabelText('Drag');
+
+      fireEvent.keyDown(draggedItem, { key: ' ', code: 'Space' });
+      fireEvent.keyDown(draggedItem, { key: 'ArrowDown', code: 'ArrowDown' });
+
+      expect(updatePositionOfRelationMock).toBeCalledWith(1, 0);
+    });
+
+    it('should not fire reorderRelation if the item is trying to go up and is the first item', () => {
+      const updatePositionOfRelationMock = jest.fn();
+
+      setup({ updatePositionOfRelation: updatePositionOfRelationMock, testingDnd: true });
+
+      const [draggedItem] = screen.getAllByLabelText('Drag');
+
+      fireEvent.keyDown(draggedItem, { key: ' ', code: 'Space' });
+      fireEvent.keyDown(draggedItem, { key: 'ArrowUp', code: 'ArrowUp' });
+
+      expect(updatePositionOfRelationMock).not.toBeCalled();
+    });
+
+    it('should exit drag and drop mode when the escape key is pressed', () => {
+      const updatePositionOfRelationMock = jest.fn();
+
+      setup({ updatePositionOfRelation: updatePositionOfRelationMock, testingDnd: true });
+
+      const [draggedItem] = screen.getAllByLabelText('Drag');
+
+      fireEvent.keyDown(draggedItem, { key: ' ', code: 'Space' });
+      fireEvent.keyDown(draggedItem, { key: 'Escape', code: 'Escape' });
+      fireEvent.keyDown(draggedItem, { key: 'ArrowUp', code: 'ArrowUp' });
+
+      expect(updatePositionOfRelationMock).not.toBeCalled();
+    });
+  });
 });
diff --git a/packages/core/admin/admin/src/content-manager/components/RelationInputDataManager/tests/RelationInputDataManger.test.js b/packages/core/admin/admin/src/content-manager/components/RelationInputDataManager/tests/RelationInputDataManger.test.js
index 52343e2b68..f8050e1123 100644
--- a/packages/core/admin/admin/src/content-manager/components/RelationInputDataManager/tests/RelationInputDataManger.test.js
+++ b/packages/core/admin/admin/src/content-manager/components/RelationInputDataManager/tests/RelationInputDataManger.test.js
@@ -389,7 +389,7 @@ describe('RelationInputDataManager', () => {
     );
   });
 
-  test('Reorder an entity', () => {
+  test('reordering an entity', () => {
     const { reorderRelation } = useCMEditViewDataManager();
     setup();
 
diff --git a/packages/core/admin/admin/src/translations/en.json b/packages/core/admin/admin/src/translations/en.json
index 2f40be8739..4ebfdcf469 100644
--- a/packages/core/admin/admin/src/translations/en.json
+++ b/packages/core/admin/admin/src/translations/en.json
@@ -554,6 +554,7 @@
   "content-manager.components.LeftMenu.single-types": "Single Types",
   "content-manager.components.LimitSelect.itemsPerPage": "Items per page",
   "content-manager.components.NotAllowedInput.text": "No permissions to see this field",
+  "content-manager.components.RelationInput.instructions": "Press spacebar to grab and re-order",
   "content-manager.components.RepeatableComponent.error-message": "The component(s) contain error(s)",
   "content-manager.components.Search.placeholder": "Search for an entry...",
   "content-manager.components.Select.draft-info-title": "State: Draft",